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Mouth pain while using an acyclovir buccal tablet. Therapy should be initiated as early as possible following the onset of signs or symptoms of herpes labialis, i. During the prodrome or when lesions appear. These include herpes zoster ( shingles ), genital herpes, and varicella ( chickenpox). Efficacy is maximised by early patient initiated treatment at the onset of prodromal symptoms. ZOVIRAX Cream should be applied 5 times per day for 4 days. Adults—Apply to the affected area (s), every three hours, for a total of six times a day, for seven days. Tell the doctor if you have any side effect that bothers you or that does not go away. Children—Use and dose must be determined by your doctor. These are not all the possible side effects of Zovirax.. Acyclovir will not get rid of the virus infection but does help sores heal faster and helps with pain relief. Acyclovir is used to treat viral infections. For adolescents 12 years of age and older, the dosage is the same as in adults. In Canada Adults—Apply to the affected area (s), four to six times a day, for up to ten days. It is also used to prevent having regular outbreaks of genital herpes. Acyclovir is an antiviral drug that is used to treat symptoms of shingles, chickenpox, cold sores and genital herpes which are all caused by herpes viruses. More about Zovirax Cream (acyclovir topical). This drug doesn’t cure herpes infections.